Frequency of the hla-b58 allele in patients suffering from spondyloarthritis

Fateme Modhejiyan,1,* Dr.sina mirzaahmadi,2 Somaye gholami,3 Narges mohammadi,4

1. Department of Genetic group, Zanjan Branch, Islamic University, Zanjan,Iran
2. Department of Genetic group, Zanjan Branch, Islamic University, Zanjan,Iran
3. Department of Genetic group, Zanjan Branch, Islamic University, Zanjan,Iran
4. Department of Genetic group, Zanjan Branch, Islamic University, Zanjan,Iran

Abstract

Introduction

Spondyloarthritis is a chronic progressive inflammatory disease that results in disorders in spine, socroiliac joints and surrounding soft tissues. this problem is common in men and typically before 45 years old. different types of spondyloarthritis include: 1) anklosing spondylitis 2) psoriatic arthritis 3) reactive arthritis 4) juvenile unknown inflammation of the joints (arthritis). in previous studies, there was a direct correlation between spondyloarthritis and hla-b27 allele. we studied the relationship between spondyloarthritis and hla-b58. this allele plays an important role in steven-johnson syndrome and diagnosis of renal chronic failure.

Methods

A total of 130 people were selected. 100 suffering from spondyloarthritis and 30 were healthy without any family history. pcr test was used to identify hla-b58 and the results were analyzed using spss software.

Results

Data showed existence of hla-b58 allele in 36 out of 100 patients and 5 out of 30 healthy people. according to the p value (0.046) there seems to be a significant relationship between occurrence of the spondyloarthritis and existence of hla-b58 allele as a predisposition allele. also, the sex is related with existence of this allele and occurance of the disease.

Conclusion

According to previous studies, hla-b alleles play an important role in development of autoimmunity diseases, therefore studied the role of hla-b58 allele. the results indicated that the hla-b58 allele was effective in the disease, so in this disease the hla-b58 should be taken into consideration.

Keywords

Spondyloarthritis, hla-b58, pcr, spss, spondylitis anklosing