The role of cellular scaffolds in biomedicine
1. fisiology reaserch center of iran university of medical science
Today, tissue engineering research is expanding extensively so that it has the potential for de novo to build organ and tissue. in order to improve the cell and tissue culture efficiency in tissue engineering, it is necessary to create an ex vivo in vivo mode of the bodys three-dimensional conditions. to achieve this goal, the target tissue cells are grown on the scaffolds. scaffolds are structures based on materials in the extracellular matrix that have been treated with different treatments. initially, the drug was used only for the transfer of medication and hormone to the body, but further research showed that these materials have the ability to maintain, maintain and even transmit the cells to the body.
In this paper, we are trying to help researchers to find out the right scaffolding with less time and less cost by using the information contained in the published articles and organized the information inside them.
Selecting the type of scaffold is the most important part of the work so that the replacement of the damaged tissue is finally seen. the scaffold not only allows the cell to be connected, but also causes the migration of cells, the transfer of biochemical factors, the release of food, waste materials and the production of cells. in order to achieve this goal, the scaffold must have some structural properties. in this paper, we will try to examine the types of these scaffolds.
research has continued to proliferate cells on scaffolds to increase the efficiency of 3d cultivation. for this purpose, it is necessary to simulate the internal environment, which is used for simultaneous culture of target cells and stromal cells. in the present paper, information on the various aspects of scaffolds, including history, gender, and types of scaffolds and their applications in medicine and tissue engineering, has been reviewed. a very diverse and convenient way to produce polyethylene (pla) and pcl described (polycarbonate) (pcl) electro phobic is a nano fibers scaffold. widely used as scaffold material adapted to structural engineering for tissue engineering. here, graphene oxide (ngo) points in electro-sponge structures of pla or pcl during the electrophysin process are aimed at enhancing mechanical properties and verifying osteobiophysics. (ngo) strongly integrates into the existing fiber with secondary interactions with electricity, and the quality of the fiber heal. the nano filtration scaffolds increase. the mechanical properties, increased hydration, adequate cytotoxicity and osteobiofic acid quality are better. therefore, they will have a very high potential for bone tissue engineering programs. the high porosity and cross-sectional area are better for adaptation and cell proliferation. pla and pcl have been successfully developed for various types of electrosurgical nano filter scaffolds.
Bio-medicine , nano scaffold , pcl