1. Department of Cellular and Molecular Sciences,Faculty of Siences,Khalij fars University,Bushehr. 2. Departmet of Biotechnology,Persian Gulf Studies and Research Center, Khalij fars University,Bushehr.
Fucoidan is a group of carbohydrates rich in sulfate found in algae and recently found in plants. the adjustment of the immune system using fucoidan can be used as a means of cutting off pathogenic processes, including cancer and pathogenic infections
Natural polysaccharides, including fucoidans, may have a direct antibacterial effect on different microorganisms . it has been shown that fucoidan by controlling the alternative and classic complementary pathways can reduce the inflammation of the gastric wall due to the activation of the complement .
Also, the daily intake of 1 g of fucoidan of the species undaria pinnatifida in the elderly helps to react antibodies to seasonal vaccines. a study showed that the fucoidan species of ascophylum nodosum increased the survival rate of caenorhabditis elegans with pseudomonas infection and reduced the toxic metabolites and minimal measurable bacterial count . studies have shown that oral or subcutaneous consumption of fucoidan results in endotoxin-induced metabolic damage . in the study of fucoidan antiviral effects, it has been shown that the fucoidan of undaria pinnatifida have been shown to increase the effects of oseltamivir in infecting different types of influenza a (h5n3, h7n2) in mouse models . it has been shown that the fucus vesiculosus fucoidan, in conjunction with dendritic cells, stimulates them and improves immune responses and activates cytotoxic t cells . fucoidan from laminaria cichroides, laminaria japonica and fucus evanescence are attached to the tlrs . the connection to the tlr-2 and the tlr-4 has enabled the activation of the nf-kb intermediates and the activation of the defense system . also, studies have shown that fucoidan of cladosiphon okamuranus have protective effects against the penetration of the new castle virus .
studies have shown that the use of fucoidan with antibiotics or alone has reduced drug resistance of germs and has inhibited their growth and death. these studies hope that the use of algae-derived fucoidans as an adjunct to its antimicrobial effects can prevent side-effects of antibiotics and microbial resistance.