The influence of metal nanoparticles on pseudomonas aeruginosa

Niloufar Rashidi,1,* Mojgan oshaghi,2 Parisa roshani asl,3

1. Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
2. Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
3. Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran



Today, the treatment of infections caused by gram-negative pathogens has become a major challenge in the medical world, because of the expanding antimicrobial resistance in the healthcare setting. among infections caused by these bacteria, pseudomonas aeruginosa as the second most frequent pathogen, has a prominent role. antimicrobial resistance has led to a serious limitation in treatment options for p. aeruginosa infections. the continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. nowadays, nanotechnology has emerged as a modern and innovative strategy to develop new formulations based upon metallic nanoparticles (nps) with antimicrobial properties. this review aims to indication a short review for approaches on the control of p. aeruginosa using various types of metal nanoparticles, their benefits, limitations and the possible modes of their action.


The information of this article was collected by searching the keywords related to the subject on the electronic databases such as google scholar, pubmed and scopus and surveying different scientific articles published in reliable online journals.


Numerous studies have been done on the metal based nanomaterials including quantum dots, various metallic and metal oxide nps. studies have shown that metals such as zinc, titanium, cadmium, magnesium, iron, manganese, copper, silicon, gold, selenium, silver and tellurium at the nano-scale, control various cellular metabolisms in p. aeruginosa and also display bactericidal and antibiofilm activities against this pathogen. the difference between the negative charge of the microorganism and the positive charge of the nanoparticle acts as an absorption electromagnet between the nanoparticle and the microbe and causes the nanoparticle to bind to the cell surface and thus can cause cell death. the generation of reactive oxygen species, binding with cell wall and change in permeability of the cell membrane, reaction with thiol groups of surface proteins of bacterial cells and inactivation of dna are the most common mechanisms of action of nanoparticles.


Based on the results of the studies, metal nanoparticles have an inhibitory effect on p. aeruginosa. therefore, they can consider as an appropriate alternative to prevent or treatment of p. aeruginosa infections. main effect on pathogens, selective toxicity to biological systems, decreasing dominant resistance and costs are the features which make metal nanoparticles the suitable candidates for biomedical applications


Pseudomonas aeruginosa, metal nanoparticles, antimicrobial, antibiofilm