Anti-inflammatory activity of nannorrhops ritichieana h. wendl extract in animal models

Shahrzad Hashemi,1,* Zahra mousavi,2 Jinous asgarpanah,3 Parvaneh najafizadeh,4

1. Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran (IAUPS).
2. Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran (IAUPS).
3. Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran (IAUPS).
4. Department of Pharmacology, Iran University of Medical Sciences, Tehran, Iran.

Abstract

Introduction

Nannorrhops ritichieana is the sole species in the genus nannorrhops in the palm family arecaceae. it is native to south western asia, in the historical region of baluchistan, from the southeast of arabian peninsula east through iran and afghanistan to pakistan. due to the study about the anti-inflammatory effect of the plant phoenix dactylifera that is also in the palm family we were promoted to assess the anti-inflammatory properties of n. ritichieana extract in animal model.

Methods

The acute anti-inflammatory effect of n. ritichieana (50,100 and 200 mg/kg ip), were assessed by carrageenan-induced paw edema method in 30 min, 1,2,3 and 4 hours after carrageenan injection, control and standard groups received normal saline and mefenamic acid. the chronic anti-inflammatory effect of n. ritichieana (100 and 200 mg/kg ip) were assessed by the cotton pellet-induced granuloma method in rats. control and standard groups received normal saline and indomethacin.

Results

In carrageenan test all studied dose of n. ritichieana significantly reduced the paw edema in comparison to the control animals (p˂0.05). anti-inflammatory activity of n. ritichieana (100 and 200 mg/kg p˂0.05) was found to be same as mefenamic acid group. in cotton pellet-induced granuloma n. ritichieana was also effective regarding the transudate and the granuloma formation amount. anti-inflammatory activity of n. ritichieana (100 and 200 mg/kg p˂0.05) was found to be same as indomethacin group.

Conclusion

The results suggest that n. ritichieana has significant anti-inflammatory effects.

Keywords

Nannorrhops ritichieana, extract, anti-inflammatory, rat.