Lack of association between hypoxia inducible factor rs11549465 polymorphism and preeclampsia

Mahdiyeh Haratisadegh,1,* Saeedeh salimi,2

1. Department of Genetics, Marvdasht Branch , Islamic Azad University, Marvdasht , Iran
2. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences



Pre-eclampsia (pe) is an obstetric disorder that may result inmaternal and neonatal mortality and morbidity. placental hypoxia has been implicated in the pathogenesis of pre-eclampsia. hypoxia inducible factor-1α (hif-1α) is activated by low oxygen tension and is a key regulator of genes involved in the cellular responses to hypoxia. the aim of this study was to evaluate the association between hif1-a snp (rs11549465) and the risk of pe.


The present case control study comprised 53 pe placenta and 55 controls. the hif1-a rs11549465 polymorphism was genotyped with pcr-rflp (polymerase chain reaction–restriction fragment length polymorphism) method.


The frequency of allels were c=89.1 and t=10.9 in control group and c=83.9 and t=16.1 in pe placenta; which there is not deffiernt statistically (p-value=0.27). the frequency of genotypes were cc=0.80, ct=0.18, tt=0.02 in control group and cc=0.68, ct=0.32, cc=0 in pe placenta; which was no statistically different (p-value=0.17).


In conclusion, our results suggest that the hif-1α rs11549465 polymorphism is not associated with the development of pre-eclampsia in the studied iranian women population.


Hypoxia, hif1-a, polymorphism, preeclampsia