1. Department of Laboratory Sciences,Faculty of Paramedicine, Gorgan University of Medical Sciences. 2. Department of Laboratory Sciences,Faculty of Paramedicine, Gorgan University of Medical Sciences.
Invasive fungal infections are a major problem for immunocompromised patients in intensive care units. morbidity and mortality rates of these infections are high because of late diagnosis and delayed treatment. moreover, the number of available antifungal agent is low, and there are problems with toxicity and resistance.
the main goal of this reviwe antifungal effect of different forms of nanodrugs such as selenium nanoparticles, itraconazole dry powders, nystatin nanosuspensins, chitosan containing liposome, in the treatment of candida and aspergillus infections
bacillus sp. msh-1 were used for biosynthesis selenium nanoparticles , itz particle size by reducing to the nanometer were using high-pressure homogenization with tocopherol polyethylene 1000 succinate, nystatin nanosuspension was prepared by wet-media milling. chitosan‐containing lipsome was made of soy phosphatidylcholine with entrapped fluorescence markers fitc-dextran 4000. low mwt amphotericin b-polymethacrylic acid nanoparticle were made by magnetic stirrer.
Nanonization of nystatin provides a novel approach to enhancing its efficacy in the treatment of oral candidiasis. nano-size drugs ,two to four times effective in candida infectious. low mwt amphotericin b-polymethacrylic was not toxic to lung epithelial cells and prevented both fungal growth and lung inflammation. se nps reduction of yeast cells was more than mold. itz np could be a very effective alternative for treating invasive pulmonary aspergillosis. chitosan-containing liposomes could be applied as a safe and effective antifungal treatment.
Therefore, nano active systems could lead to more efficient and less invasive therapeutic outcome, contributing to the development of personalized treatment for several infectious diseases.