Antioxidant and anti-inflammatory properties of natural compounds
Antioxidant and anti-inflammatory properties of natural compounds
Azadeh Teimury,1Elahe Seyed Hosseini,2Elahe Mahmoodi Khaledi,3,*
1. Department of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan, Kashan, Iran 2. Anatomical Sciences Research Center, Basic Sciences Research Institute, Kashan University of Medical Sciences, Kashan, Iran Gametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran 3. Department of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan, Kashan, Iran
Introduction: Oxidation protection is thought to prevent some chronic diseases. Inflammation occurs in bacterial, viral, fungal or parasitic diseases, and millions of people around the world suffer from inflammatory problems caused by such diseases. According to the treatment of inflammation based on chemical drugs, including non-steroidal anti-inflammatory drugs and glucocorticoids, which have various side effects such as heart toxicity, hepatotoxicity and immunodeficiency, natural anti-inflammatory products have been considered by many researchers as an alternative to conventional therapies for inflammatory disorders due to their relative safety, efficacy, and availability. These products contain compounds such as sugars, pantothenic acid, phenolics, flavonoids, fatty acids, vitamins, minerals.
Methods: Many studies have reported that there is a relation between the antioxidant and anti-inflammatory properties of natural compounds. In this review, first, oxidation and inflammatory process and the bioactive compounds especially phenolic compounds in natural products will be examined in general. Then, based on the results of various studies, mode of action of phenolic compounds as antioxidant and anti-inflammatory agents, antioxidant tests, expression of inflammatory factors such as interleukins and immune modulators, will be evaluated at in-vitro and in-vivo levels. The mechanisms of these effects will also be investigated as much as possible.
Results: Natural compounds are a wide group, ubiquitous in plant-based foods, and possess a remarkable anti-inflammatory capacity due to their multiple inhibitory activities of proinflammatory mediators. Form various studied and researches, it will be concluded, natural products have significant antioxidant and anti-inflammatory effects that exert anti-inflammatory effects by acting on various drug targets and cellular messaging pathways. The mechanism of action may be by preventing the formation of free radicals in inflamed tissues.
Conclusion: Researchers propose dietary natural compounds especially phenolics as a potential natural alternative for the treatment of inflammation and related diseases, with minimal or null adverse side effects.