Cellular senescence pathway associated to pulmonary arterial hypertension
Cellular senescence pathway associated to pulmonary arterial hypertension
Akram Gholipour,1,*Maziar Oveisee,2Mahshid Malakootian,3
1. Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences 2. School of Medicine, Bam University of Medical Sciences, Bam 3. Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences
Introduction: Pulmonary arterial hypertension (PAH) is a frequent complication of congenital heart disease (CHD) and relates to type of the underlying cardiac defects and repair history. Some common underlying causes of pulmonary hypertension include high blood pressure in the lungs' arteries due to some types of congenital heart disease, connective tissue disease, coronary artery disease, high blood pressure, liver disease. The aim of this study was to evaluate the important signaling pathways in PAH.
Methods: The expression profiling array of patients with PAH and Control samples were obtained from the GEO database (GEO accession: GSE131793), and the samples were analyzed. Genes with differential expression patterns were isolated with the GEO2R by P.value < 0.05 investigation. Signaling pathways analysis was performed using Enrichr database.
Results: The results showed that 3363 genes had differential expression among the samples. In addition, pathway analysis demonstrated that cellular senescence with p= 0.00009805 is the main important signaling pathways in PAH patients and RB1, CDKN1A, ITPR3, PIK3R1, ETS1, MUC, ATM, MYBL2, MAP2K3 were important genes among differential expressed mRNAs in this pathway.
Conclusion: All in all, our analysis in line with previous reported showed that analysis the expression of cellular senescence genes might help to find novel diagnostic biomarker for PAH.