• The Effect of Sperm k + and SLO3 Channels on Sperm Motility in Male Infertility
  • Ali Ahmadi,1,* Reza Jebraeili,2 Dariush D. Farhud,3
    1. BSc. Student, Student Research Committee, Faculty of Medical Sciences, Islamic Azad University, Sari, Iran
    2. BSc. Student, Student Research Committee, Faculty of Medical Sciences, Islamic Azad University, Sari, Iran
    3. School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


  • Introduction: SlO3 channels are regulated by pH, which may be expressed in mammalian sperm and may play a role in its alkalization. While growing evidence supports the vital role of potassium (K +) channels in somatic cells. Little is known about the localization and regulation of these channels in mammalian sperm. Previous studies have reported that SLO channels are the major K + channels in humans and mice. The sperm of these channels belong to the SLO gene family. It plays a vital role in regulating sperm volume and has also been shown to play a role. The sequence of changes that occur during capacity. Notably, such a regulatory role is mainly performed by SLO3 in mice, which includes SLO1 and SLO3 in human sperm. Be. The SlO3 channel is very important for male fertility.
  • Methods: This study is a secondary study (review) with a narrative approach in 2022 that searches for keywords such as K + channels, SLO3 channels, Spermatozoon, Male infertility, Sperm Motility in reputable databases including , Science Direct, Web of Science, Scopus. In this study, the relevant studies were entered based on the inclusion and exclusion criteria. A total of 15 articles were reviewed, of which 10 articles were included in the study.
  • Results: According to studies from various articles, the results are that, in order to be successful in fertilization, sperm must decode environmental signals that require a set of ion channels. Recent findings suggest that K + and Cl- channels are involved in some of the major functions of sperm. This study examines the evidence for the involvement of K + and Cl- channels in motility, maturity, acrosome reaction, and progress in identifying molecular identities and their regulatory states. Improving our insights into how these channels work strengthens our ability to overcome some infertility problems, improve animal husbandry, preserve biodiversity, and develop selective and safe contraceptive tools for men. The observed effects of TEA are consistent with its high capacity to block K + channels. Regardless of whether they open or close. Due to the decrease in sperm motility, we also saw a significant decrease in sperm velocity (VCL, (VSL) and VAP) parameters and in cross-frequency pulse (BCF). Consistent with these findings, non-selective blockage of K + channels has also been shown to inhibit progressive movement in human sperm. In addition, our data also demonstrate the importance of K + conductivity for sperm motility during in vitro capacity building.
  • Conclusion: According to the results, high-power screening methods can accelerate the identification of new factors that enhance sperm motility. In addition, it is important to confirm that these locomotives do not have any adverse effects on the developing fetus.
  • Keywords: K + channels, SLO3 channels, Spermatozoon, Male infertility, Sperm Motility