• An overview of stem cells
  • Melika Alizadeh,1,*
    1. Pardis Sharif High School


  • Introduction: In recent years , remarkable progress has been achieved in connection with stem cells , which promises new treatment solutions in difficult - to - treat diseases . These cells , which are present in all multicellular organisms , have the ability to divide and transform into very specific cells and are also able to replace lost and damaged cells . The self - renewal and differentiation ability of these cells promises a bright future in the field of regenerative medicine , cell therapy and pharmaceutical research . New technologies not only provide an unlimited source of autologous stem cells , but also enable the use of non - autologous cells . Of course , the therapeutic use of stem cells is associated with many limitations and obstacles , and therefore more research is necessary to understand their biology . In this article , the basic concepts , applications and limitations of use , and the perspective of the use of stem cells in the future have been reviewed .
  • Methods: 1. Gulotta LV , Chaudhury S , Wiznia D. Stem cells for augmenting tendon repair . Stem cells international . 2012 ; 291-431 . 2. Améen C , Strehl R , Björquist P , Lindahl A , Hyllner J , Sartipy P. Human embryonic stem cells : Current technologies and emerging industrial applications . Critical Reviews in Oncology / Hematology . 2008 ; 65 ( 1 ) : 54-80 . 3. Baraniak PR , McDevitt TC . Stem cell paracrine actions and tissue regeneration . Regenerative medicine . 2010 Jan ; 5 ( 1 ) : 121-43 . 4. Buecker C , Geijsen N. Different flavors of pluripotency , molecular mechanisms , and practical implications . Cell Stem Cell . 2010 Nov 5 ; 7 ( 5 ) : 559-64 . 5. Van der Jeught M , Taelman J , Duggal G , Ghimire S. Lierman S , Chuva de Sousa Lopes SM , et al . Application Of Small Molecules Favoring Naive Pluripotency during Human Embryonic Stem Cell Derivation . Reprogram . 2015 Jun ; 17 ( 3 ) : 170-80 . Cell 6. Guilak F , Cohen DM , Estes BT , Gimble JM , Liedtke W Chen CS . Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix . Cell Stem Cell 2009 ; 5 ( 1 ) : 17-26
  • Results: Stem cells exist as normal cells in embryonic and adult tissues . Recent studies in the direction The proof of the strong and powerful role stem cells in the field of treatment has begun . Stem cells with self - renewal potential and differentiate into special types of somatic cells . Their ability to produce new cells in medicine , drug discovery , Cell therapy and research are very important . In the past decades , many efforts have been made to find safe methods The cost and progress of stem cell cultivation has been done . The purpose of this review article : 1 ( Explanation of the use of stem cells In medicine , drug discovery is sampling of diseases and toxicology studies . 2 ( Preparation of a summary of recent developments Stem cell technology , advantages and disadvantages of common cultivation methods .
  • Conclusion: The result of this discussion shows that the use of new cultivation methods can be used for the optimal use of stem cells be effective . Next , topics such as : types of stem cells , use of stem cells in drug discovery : 1 ) targeted recognition , 2 ) large - scale screening , 3 ) sampling of diseases , 4 ) drugs that stimulate proliferation and growth / poison studies We are dealing with science / automatic cultivation systems / combinatorial microarray and microfluidic cultivation systems .
  • Keywords: stem cell technology , medicine , drug discovery