amin hajhosseini,1,*hamidreza karimi kamar,2Parya roohi,3Mahtab montazeri,4Maryam Esmati,5
1. Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran 2. medical lab science student, Azad Islamic university, Ardabil, Iran 3. medical lab science student, Azad Islamic university, Ardabil, Iran 4. Medical labratory science student at kashan university of medical science, Kashan, isfahan, iran 5. Medical laboratory science student at Mazandaran University of Medical Sciences, Sari , Iran
Introduction: Nano biosensors which based on nanomaterial are used in analytical determination through a specific circumstance. It is also boost by nanomaterial existence. These biosensors are DNA-based with electrochemical and FET-based transduction which have diverse kinds of nanomaterial like metal nanoparticles, nanowires, etc. affinity-based biosensors (ABBs) is compelling devices for affordable and early recognitions. SARS-COV2 appear to be linked with milder infections but it is rapidly spread to become global pandemic problem. Cov family is enveloped, positive-sense, singlestandarded RNA viruses that could spill over the mammals and birds. The biosensor’s fast response time, high specify, etc, permit them for POC use and accomplishment of current process of screening and monitoring. This article tries to illustrate new recent advances of biosensors in nano field.
Methods: In this systematic review, the data required for this study were collected using keywords and based on reliable databases such as Google Scholar, PubMed, Scopus and ProQuest. In this study, our statistical population includes all articles registered until 2022. After reviewing the relevant findings and evaluating the quality of the obtained data, 17 articles were analyzed.
Results: According to the sources there are two type of nanobiosensores: 1- bottom-up nanostructures (lithography 51, 58) 2- top-down nanostructures (lithography 47-50, 44). First one usage are in clinical application especially in places where no storage facility exist, being balancer factors, colloidal plasmatic nanoparticles (NPs) synthesize is in same with bottom-up approach, for enhancing the stability extensive endeavor apply toward PNP synthesis, etc. In contrast top-down benefits are long shelf-life, effortless portable, also used for detection, etc. This variety of differences caused researches to be done in fabrication technique for high performance nanoplasmonics such as e-beam, mask lithography, etc. As long as performing nanofabrication technique began to count as sensor transducers. So these nanostructures illustrate capable advantages against SPR, for instance handling need for complex light coupling system, etc. Nowadays a few nanobiosensors available in streets but it is not used for laboratories or clinics for routine tests. Even researches is continued to merge nanotechnology provided assets which could beat SPR biosensors.
Conclusion: Plasmonic materials and nanostructures have incomparable potential for comprehension of noble enabling biosensor technologies. Plasmonic biosensors can suggest analytics label-free recognition of any type with sensitivities and real-time one-step format.
Plasmatic and Nanoplasmonic could be used in portable and user-friendly devices at needed occasions. For developments and designs several factors may be considered, include metal selection of plasmatic, the particle geometry, biorecognition interface, etc. after take account all aspects these techniques could be used in fast detection of cancer, screening huge amount of population or routine tests of food or water contaminant.