Regulation of HIF-1 by microRNAs in various cardiovascular disease
Regulation of HIF-1 by microRNAs in various cardiovascular disease
Leila Abkhooie,1,*
1. Department of Medical Biotechnology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Introduction: Today, we see an increase in death due to cardiovascular diseases all over the world, which has a lot to do with the regulation of oxygen homeostasis. Also, hypoxia-inducing factor 1 (HIF-1) is considered a vital factor in hypoxia and its physiological and pathological changes. HIF-1 is involved in cellular activities including proliferation, differentiation, and cell death in endothelial cells (ECs) and cardiomyocytes.
Methods: Pubmed, Google Scholar
Results: The molecular regulation of HIF-1 is considered to improve therapeutic approaches in clinical diagnoses of cardiovascular diseases.
Conclusion: In this review, we studied the collected data on HIF and the complex molecular network under its control in hypoxic conditions. Understanding the mentioned molecular pathways can be used in applying more efficient treatment methods for cardiovascular diseases.