• The Effect of Probiotic on Liver Enzymes and Lipid Profile in Animal Model of Breast Cancer
  • Nahal Hefzi,1 Rasoul Sharifi,2,*
    1. Department Of Biology, Ahar Branch, Islamic Azad University, Ahar, Iran.
    2. Department Of Biology, Ahar Branch, Islamic Azad University, Ahar, Iran.


  • Introduction: Probiotics have beneficial effects in liver protection and modulating of serum lipid profile. Therefore this study assessed levels of liver enzymes and lipid profile in an animal model of breast cancer following administration of probiotics.
  • Methods: In this study, 48 animals of Balb/C mice were divided into 6 groups: 1-the healthy control, 2-the cancer control, 3-the healty group receiving 0.5 g of probiotics, 4-the cancer group receiving 0.5 mg of probiotics, 5-the cancer group receiving 1 g of probiotics and 6- the cancer group receiving 1 g of probiotics for 3 weeks. 4T1 cell line was used to induce cancer. Blood samples were used for evaluation of levels of lipid profile and liver enzymes by calorimetric methods. Data were analyzed using SPSS-Ver-18 and one-way ANOVA, T-test, Kruskal-Wallis and Mann–Whitney U tests methods (p <0.05).
  • Results: The results of this showed that probiotics resulted in a non-significant increase in HDL, and significanr decrease of LDL,TG and cholestrol levels (p=0.01, 0.006 and 0.02 respectively). and non-significant decrease of ALP,AST and ALP in the treatment group compared with untreated cancerous group.
  • Conclusion: The use of probiotics resulted in improvement of liver enzymes and lipid profile abnormalities in animal breast cancer model.
  • Keywords: Probiotics, liver enzymes, lipid profile, Breast cancer