• Effect of vitamin E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers and hormonal functions in PCOS (polycystic ovary syndrome): a systematic review and meta‐analysis
  • Erfan Mohammadi-Vajari,1,* Ghazale Tefagh,2 Mahbube Ebrahimpur,3 Moloud Payab,4 Bagher Larijani,5 Zhaleh Shadman,6
    1. School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
    2. Advanced Diagnostic and Interventional Radiology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
    3. Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
    4. Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
    5. Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
    6. Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.


  • Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy among reproductive-age women. Various therapeutical approaches are currently used to manage or control symptoms associated with PCOS. This systematic review intended to assess the effects of Vit E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers, and hormonal functions in PCOS women based on the clinical trial’s results.
  • Methods: The databases including PubMed, Scopus, Cochrane, Web of Science, and Embase were used to find all relevant studies. The authors reviewed all relevant clinical trials via systematic evaluation of abstracts and titles. Searches were conducted on August 1, 2020. After the initial search and reading of the article’s title and abstract, 353 articles were reviewed; finally, 12 articles met the inclusion criteria.
  • Results: We found that vitamin E can improve PCOS hormonal profile by decreasing testosterone and LH levels and by increasing progesterone and FSH levels. It can also reduce insulin resistance, cholesterol, LDL, and TG levels among these patients, it can also improve their cardio-metabolic profile. We also found that vitamin E supplementation can decrease oxidative stress in PCOS.
  • Conclusion: Vitamin E supplementation can positively affect the patients who are diagnosed with PCOS in regards to metabolic and hormonal parameters.
  • Keywords: Vitamin E, PCOS, cardiometabolic risk factors