• Relationship between serum Vitamin D and Adipokines in diabetes type 2
  • Vahid Pouresmaeil,1,* Saleh Aboodi,2 Masoud Homayouni Tabrizi,3
    1. Department of Biochemistry, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.
    2. Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
    3. Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.


  • Introduction: Diabetes is one of the metabolic diseases in which various factors play a role. The role of adipokines in causing inflammation in adipose tissue and subsequent brief inflammation in the body is known, which can be the cause of diabetes and increase the speed of disease progression and its serious complications. Research has shown that adipokines and vitamin D may be associated with the onset or progression of type 2 diabetes. Objective: The aim of this study was to investigate the relationship between serum vitamin D and adipokine levels in type 2 diabetic patients.
  • Methods: This case-control study was performed on 30 patients with type 2 diabetes in Mashhad hospitals in 2020 and 30 healthy individuals. The lipid profile, creatinine, uric acid, fasting blood sugar, HbA1c, and blood pressure were registered. Insulin resistance was measured using the HOMA-IR formula. Serum levels of vitamin D, Adiponectin, and Resistin were measured by ELISA method. The software used in this study is SPSS v.24, and the significance level of the tests is considered less than 5%.
  • Results: Thirty patients with a mean age of 52.90±10.38 years including 16 women and 31 healthy individuals with a mean age of 48.53±10.36 years including 16 women were studied. BMI level (P=0.002), systolic blood pressure (P=0.034), fasting blood sugar (FBS) level, HbA1c, insulin, insulin resistance, and resistin levels in diabetic patients were significantly higher than the control group (P<0.05). Vitamin D and adiponectin levels were significantly different between the two groups which the control group was significantly higher than the case group (P<0.05).
  • Conclusion: Our results showed that resistin and adiponectin had a significant inverse relationship with vitamin D. In addition, resistin has a significant direct relationship with HbA1C and FBS, while adiponectin has a significant inverse relationship with insulin resistance, insulin, and creatinine levels. Therefore, controlling these parameters can help improve diabetes.
  • Keywords: Type 2 diabetes, Adiponectin, Resistin, Vitamin D