Introduction: Quercetin is a flavonoid presenting potential protective effects against neurodegeneration, including antioxidant, metals chelating, anti-inflammatory, and anti-apoptotic effects. Numerous studies have designed various nanoparticles (NPs) to improve quercetin properties.
Methods: Here, the protective properties of quercetin against neurodegeneration is reviewed and then, new nanoparticles and their effects on quercetin properties is reported.
Results: NPs prepared by different researchers improved biological effects of quercetin. In addition to enhancing the quercetin solubility and bioavailability, the NPs could ameliorate the antioxidant and anti-inflammatory properties of quercetin.
Conclusion: This study reviews efficiency of quercetin NPs (QNPs) and quercetin-carrier NPs and suggests the NPs can be effective to improve the neuroprotective effects of quercetin.