Introduction: Multiple sclerosis or MS is one of the diseases that have been seen in many countries of the world, including Scandinavian countries, North America, and Iran, in the last two decades.
The aim of this study is the effectiveness of drugs that play a role in reducing anxiety (diazepam and lorazepam) on the Calnexin protein involved in MS.
Methods: This research was done by descriptive-analytical method.
In the first step, the desired development was extracted from the PDB site.
Important points such as high protein resolution, more number of nucleotides, less number of chains were given effect in protein selection.
At the same time, the three-dimensional structure of two drugs, diazepam and lorazepam as ligands, was extracted from the pubchem site.
Then the protein preparation step was done in the Chimera 1.15 program, which includes:
1) Selection of a chain,
2) Removal of additional items, including ion removal, water removal,...
3) Protein storage in pdb format and protein preparation for docking process were done.
The docking process was done with the pyrx program.
First, diazepam drug and then lorazepam drug entered the docking process as a ligand to bind to
the receptor (protein).
The x, y, and z coordinates of the area were removed from deepsite.
Results: It was observed that these drugs, especially diazepam, have created an acceptable level of binding, and according to the above results, the effectiveness of diazepam is better.