• Ostrich oil as a treatment for chronic anal fissure: a randomized clinical trial
  • Masoumeh Taghizadeh,1 Ali Mohammad Madahian,2 Gholamreza Bazmandegan,3 Zahra Kamiab,4 Zahra Kourkinejad Gharaei,5,* Fatemeh Kourkinejad Gharaei,6
    1. Rafsanjan University of medical sciences, Rafsanjan, Iran
    2. Rafsanjan University of medical sciences, Rafsanjan, Iran
    3. Rafsanjan University of medical sciences, Rafsanjan, Iran
    4. Rafsanjan University of medical sciences, Rafsanjan, Iran
    5. Faculty of medicine, Rafsanjan University of medical sciences, Rafsanjan, Iran
    6. Department of infectious diseases, Kashan University of medical sciences, Kashan, Iran


  • Introduction: Introduction: Chronic Anal fissure is a rupture in the anal canal for duration of more than 8 weeks. Due to the recurrence of the disease, researchers are always in search of new medicines for medical therapy. Ostrich oil has anti-inflammatory and analgesic effects on wounds. It has angiogenesis and re-epithelialization effects, too. In this study we investigated the effect of ostrich oil on the treatment of chronic anal fissure.
  • Methods: Material and methods: In this clinical trial, 150 patients with chronic anal fissure were randomly divided into intervention and control groups. The intervention group received Glyceryl trinitrate (GTN) 0.2% -Ostrich oil 50% and the control group received 0.2% GTN ointment until the disease recovered and meant 4 and 5 weeks, respectively. Patients were follow up for symptoms of recurrence. The collected data were analyzed by SPSS 24.
  • Results: Results: Most of the patients in this study were women. The interaction between group and time showed that the slope of decreasing the mean pain score at the time of intervention in the intervention group was significantly higher than the control group (P <0.001). Wound grade (P = 0.620) and bleeding grade (P = 0.719) in the two groups showed the same response to treatment. In the first two months after cessation of treatment, patients in the control group experienced a recurrence of the disease 2.63 times more than patients in the intervention group (P = 0.001) and up to 4 months after cessation of intervention 1.90 times more than patients in the intervention group (P = 0.003). At the end of the intervention, the effect of the intervention on the pain score disappeared, wound grade relapsed with p = 0.004 and p = 0.004 and bleeding grade relapsed with p = 0.001 and p = 0.013 in 2-months and 4-months follow-up, respectively.
  • Conclusion: Discussion: The results of this study showed that ostrich oil can possibly reduce pain in patients with chronic anal fissure during treatment, accelerate healing and reduce the course of treatmen and prevent recurrence of the disease, especially early recurrence after healing and it can be used as a complementary treatment.
  • Keywords: Chronic anal fissure, Ostrich oil, Glyceryl trinitrate, Healing, Recurrence, Anal fissure