Introduction: The purpose of this study is to investigate which of the two drugs, tecfidera and
mitoxantrone, has a better effect on the MBP protein.
Methods: In this descriptive-analytical study, we first downloaded the most appropriate
three-dimensional structure of MBP protein from www.uniport.ir in pdb format.
Then the protein chains were analyzed using Chimera software. The most suitable
chain was chain E, which had more amino acids than other chains and the largest
chain of MBP protein. This software removed all the solvents and water
molecules and added hydrogen to it and subjected the protein to charge
induction and finally saved in pdb format.
Results: according to the docking results of these two drugs, the binding affinity
of mitoxantrone is more negative, compared to Tecfidera, it has better
performance and effectiveness
Conclusion: As a result, mitoxandrone drug is more effective for treatment.