1. Environment Research Center, Research Institute for Primordial Prevention of NonCommunicable disease, Isfahan University of Medical Sciences, Isfahan, Iran 2. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Introduction
Hydatid cyst is the larval stage of echinococcus granulosus which develops in
various human and livestock animals tissues. this hydatid cyst composed of several layers.
previous investigations have shown that the prevalence of hydatid cyst in cancer patients is
significantly lower than in healthy individuals. in animal models preventive effect of the hydatid cyst
antigens in reduction of tumor growth has been shown. due to the effect of live protosculex and hydatid cyst antigens on reducing the growth of cancer cells in culture medium, in this study
therapeutic effect of hydatid cyst liquid on the growth of melanoma tumor in mice (c57 black) has
been investigated.
Methods
In this experimental study, the population studies were c57 black mice. six groups of
mice were injected with 106 melanoma cells in their chest site subcutaneously. then the mice were
injected with hydatid cyst fluid either with or without albendazole. from the second week, the tumor
size was measured using a calipers and tumor area was calculated and the mean tumor area
compared with those of control groups using one-way anova test.
Results
The mean tumor area, in groups which injected with hydatid cyst fluid (case groups), was
less than the mean tumor area in the control groups and this difference was statistically significant
Conclusion
This study showed that hydatid cyst fluid may have therapeutic effect on melanoma
cancer growth.
