The role of oxidative stress in ischemic stroke patients, a case – control study

Afsoon Talaie,1,* Fardin faraji,2

1. MSC of Nutrition , Phd Candidate Of Biochemistry, Health Department , Islamic Azad University, Arak Branch, Iran
2. Associate professor of Neurology, Arak University Of Medical Sciences, Arak , Iran



in the past few years, oxidative stress was attended as one of the causal factors of ischemic stroke. in terms of the role of genetic, geographic and ethnic factors in the prevalence of stroke, we designed the study to compare the oxidative stress of stroke patients with normal healthy subjects in this geographic area.


In this case-control study, 36 patients older than 50 years with ischemic stroke and 45 healthy age and sex matched subjects, were enrolled . 10 cc blood was drawn from all subjects. the samples were centrifuged and the plasma was separated. to assess total antioxidant capacity ( tac ), lipid peroxidation ( malon dialdehyde , mda ) frap-tba and hu methods were used respectively and thiol level was also measured . the result was analyzed by using t-test in both groups.


The result showed that total antioxidant capacity () and thiol plasma levels were lower in stroke patients than healthy subjects, but only the thiol group was significantly different (p=0.525, p= 0.001 respectively ). on the other hand lipid peroxidation ( mda ) showed a slight but non-significant difference in stroke patients compared with controls.


These findings suggest that oxidative stress in patients with acute ischemic stroke may be the result of an imbalance in oxidant/antioxidant homeostasis. practically it may be useful to recommend antioxidant medication or diet to these patients.


Free radicals, ischemic stroke, oxidative stress