Micrornas as a molecular diagnostic tool for recurrent implantation failure

Scarlet Babian,1 Nassim ghorbanmehr,2,* Saghar salehpour,3 Leila nazari,4

1. Department of Biotechnology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran
2. Department of Biotechnology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran
3. Department of Obstetrics and Gynecology, Infertility and Reproductive Health Research Center , Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of medical Sciences, Tehran, Iran



Recurrent implantation failure is refers to the condition that a woman fails to achieve clinical pregnancy after at least three cycles of embryo transfer. successful implantation requires the transfer of a good quality embryo to a receptive endometrium. a high quality embryo is in turn, the result of fertilization of a mature oocyte by a viable and functional sperm. in recent years, the necessity of more precise and clinically useful tests for prediction of the quality of sperm, egg and the receptivity of endometrium is demonstrated. without robust and predictive tests the therapeutic approach has gain limited outcome. recently micrornas are considered as significant and specific biomarkers for diagnosis of sperm and oocyte quality, ovarian reserve and successful implantation. in addition the researchers proved that circulating micrornas in plasma, serum and follicular fluid have useful information about ovarian function which is important in fertility and ivf results.


We have studied fifty articles about micrornas as gene regulators in endometrial receptivity, implantation and healthy embryonic development published from 2008 to 2017.


The studies show that mir-320a, mir-132 and mir-29a are related to oocyte quality. mir-27b, mir-34c and mir-21 are related to sperm quality. also there are some important micrornas which are associated with endometrial receptivity and implantation such as mir-494-3p.


This survey shows that micrornas can serve as important biomarkers for molecular diagnosis of infertility specially in rif cases and they may be used as a tool for prediction of ivf treatment outcomes in the future.


Infertility, recurrent implantation failure, micrornas, biomarkers