Histopathological and clinical characteristics in patients with triple-negative breast cancer from 2012 to 2016, tehran: a cross-sectional study

Hesam adin Atashi,1,* Mohammad hadizadeh,2

1. School of Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
2. Department of Surgery, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran



Breast cancer (bc) is the most common cancer in women within the world. according to estimate of american cancer association, approximately 246,660 invasive bc will diagnose and 40,890 deaths occur in 2017. one of aggressive type of bc is triple-negative breast cancer (tnbc) that defined as without estrogen receptors, progesterone receptors, and human epidermal growth factor (her2). this study was performed to determine the histopathological and clinical characteristics of tnbc patients in hospitals in tehran.


This analytic cross-sectional study has performed in 5 educational and private hospitals in tehran since 2012 to 2016. this study conducted 100 consecutive tnbc patients that our data were collected from their medical records in hospitals’ archives such as immunohistochemistry (ihc) report, demographic characteristics, and metastatic information. inclusion criteria for this study were patients with primary invasive breast carcinoma with triple negative pathological samples. p-value ≤ 0.05 was considered statistically significant.


The mean age of patients was 49.7 (±12.2) years and the mean age of patients with positive and negative metastasis was 52.06±13.25 and 49.16±12.01 years respectively. 78 (81.3%) of patients were type of invasive ductal carcinoma with negative metastasis. there were significant relationship between family history (p=0.001) and lymphatic involvement (p<0.001) with metastasis. negative metastatic lymphatic involvement (44-95.7%) was more than positive one (16-29.6%). the number of patients with stage iia, iib, iiia, iiib, and iiic were 32, 14, 12, 1, and 3 respectively, that were negative in metastasis. hence, the patients with type iv were 18 with positive metastasis. the number of patients with grade ii and iii were 53 and 47, respectively.


: in this study revealed involved characteristics were age, family history, types, stage, and grade of tumor. negative family history was significantly more than positive one (p=0.001). about stages, iia and iiib were significantly more and less than other stages (p˂0.001), respectively.


Histopathological, triple-negative breast cancer, tehran