Evaluating the antioxidant status and oxidative stress in type 1 diabetes patients
Nasim Amiri kojuri,
1,* Amir hossein esmaeili,
2
1. Department of Medical Science, Islamic Azad University, Babol Branch, Babol, Iran
2. Department of Medical Science, Islamic Azad University, Babol Branch, Babol, Iran
Abstract
Introduction
In type 1 diabetes, the increase in oxidative stress in body appears as the result of the increase in free radicals production or the disorder in the antioxidant defense. evaluating the antioxidant status and oxidative stress in type 1 diabetes patients is the aim of present study.
Methods
In this study 30 type 1 diabetic patients referring to the shahid beheshti hospital in nowshahr as well as 30 healthy persons aged 14-30 years old were studied. blood sample was taken from all participants when they were on fast state, then the serum separation was done. the glucose serum density, cholesterol, triglyceride, ldl – c, hdl- c, uric acid, h2o2, glutathione measured. the datas were evaluated and assessed using t– test.
Results
Cholesterol and triglyceride density were significantly higher in patients comparing with healthy people. the hdl-c level showed a decrease in the patients significantly. the glucose level, ldl-c, uric acid, glutathione and h2o2 in both two groups had no significant change.
Conclusion
Regarding the results, the type 1 diabetic patients status has to be considered for the oxidative stress. also, natural antioxidants are recommended to be used.
Keywords
Antioxidant, oxidative stress, type 1 diabetes
