Prevalence and antimicrobial resistance properties of extended-spectrum beta-lactamases (esbl) producing escherichia coli isolated from the cases of urinary tract infections

Fateme Pourhatami,1,* Mohammad javad gharavi,2 Bahareh tavakoli-far,3

1. 1Department of Basic Sciences, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
2. Department of Parasitology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
3. Department of Physiology and Pharmacology, Alborz University of Medical Sciences, Karaj, Iran.

Abstract

Introduction

Extended-spectrum beta-lactamase (esbl) producing escherichia coli is the most prevalent cause of urinary tract infections (utis). the present research was done to study the prevalence and antibiotic resistance properties of esbl and non-esbl producing escherichia coli strains isolated from the cases of utis.

Methods

Five-hundred and one urine samples were collected and cultured for e. coli. positive samples were analyzed for presence of esbl. antibiotic resistance pattern of strains was analyzed using disk diffusion method.

Results

Three-hundred and twenty-seven out of 501 (65.26%) urine specimens were positive for e. coli. older than 40 years male (65.21%) and also younger than 20 years female (96.77%) had the highest prevalence of e. coli. prevalence of esbl and non-esbl producing strains were 15.29% and 84.70%, respectively. esbl e. coli harbored the highest prevalence of resistance against ampicillin (100%), ceftriaxone (100%), cefalexin (98%) and piperacillin (96%). non-esbl e. coli strains harbored the highest prevalence of resistance against ciprofloxacin (76.89%), ampicillin (72.92%) and gentamicin (68.95%).

Conclusion

Imipenem, nitrofurantoin and tobramycin had good activity against both esbl and non-esbl producing e. coli strains. further researches are required to found other epidemiological aspects of esbl and non-esbl producing e. coli strains isolated from utis.

Keywords

Extended-spectrum beta-lactamase, escherichia coli, antibiotic resistance, urinary tract infections.