Effect of ethanolic extract of maize kale on polycystic ovary syndrome induced by letrozole in adult female rats

Shima Monavarian,1,* Mohammad shakiba,2

1. Islamic azad university of science and research,Shohadaye hesarak Blvd,Daneshgah square,Shahid Satari freeway،Tehran,Iran
2. Islamic azad university of science and research,Shohadaye hesarak Blvd,Daneshgah square,Shahid Satari freeway،Tehran,Iran

Abstract

Introduction

Polycystic ovary syndrome (pcos) is one of the most common causes of infertility and one of the most common endocrine disorders that occurs in a high percentage of women.

Methods

In this experimental study, 48 female wistar rats were used and divided into 8 groups of 6 included: healthy control group: animals under controlled conditions with water and food, pcos control group: animals induced polysaccharide syndrome by letrozole induction, healthy experimental groups received 50, 100 and 200 ml of alcoholic extract of corn silks. received letrozole, after inducing polycystic ovarian syndrome, about 50, 100 and 200 ml of alcoholic extract of corn silks. at the end of the treatment period, serum parameters of lh, fsh, testosterone, and estradiol were evaluated. the ovarian tissues were also separated and stained with hematoxylin and follicular counting

Results

Compared to pcos control group, serum estradiol and testosterone levels in pcos group under treatment at a concentration of 200 mg/kg of a hydroalcoholic extract of corn silks decreased significantly. compared to the pcos group, there was a significant increase in the number of corpus luteum and follicular cysts, and applying doses of 50, 100 and 200 ml of alcoholic extract of corn silks significantly reduced the number of corpus luteum and follicular cysts (p <0.05)

Conclusion

Alcoholic extract of corn silks has been effective in improving serum estradiol and testosterone level and increasing the corpus luteum and decreasing follicular cyst in pcos.

Keywords

Polycystic ovary syndrome, corn silks, letrozole, female wistar mice.