Given the inappropriate use of antibiotics and prevalence of resistant bacteria, there is urgent need for antibacterial drugs that have fewer side effects than antibiotics. satureja bachtiarica is a medicinal plant which had many uses in traditional medicine. in this study, ethanol leave extract of this plant is tested on coagulase negative staphs.
In this experimental study, after collecting and drying the plant extract, the ethanolic extract of the plant was extracted by soxhelet method. then, the antibiotic resistance pattern of cons strains to cefoxitin, tobramycin, kanamycin, amikacin, gentamicin, was assessed. to evaluate the antibacterial effects, the mic test performed by using micro dilution broth method.
The results of this study showed that the antimicrobial effect of satureja extract is concentration dependent. the results of the antimicrobial effects of extracts, indicate that alcoholic extract in all dilutions have an antimicrobial effect on the cons bacteria also, antibacterial effect of satureja bachtiarica extract compared with common antibiotics. the results show that cons have highest resistance against cefoxitin and highest sensitivity to gentamicin. however, in 200 and 100 mg/ml concentrations the extract have higher antibacterial effect.
According to the results of this study, ethanol extracts had growth inhibitory effect on coagulase negative staphs. therefore, this plant has the potential to be evaluated as an alternative or adjunct to antibiotics to treat coagulase negative staph infections.