1. Department of Microbiology, Shiraz branch, Islamic Azad University, Shiraz, Iran. 2. Department of Genetics, Colleague of science, Kazerun branch, Islamic Azad University,Kazerun, Iran.
Helicobacter pylori (h.pylori) is a flagellated, spiral- shaped, microaerophilic gram negative bacterium that colonizes stomach mucosa and causes upper gastrointestinal diseases, such as gastric inflammation, chronic gastric ulcers and gastric carcinoma. chronic inflammation plays an important role in the pathogenesis of autoimmune diseases, allergies and cancer. inflammatory cytokines, such as il-19 play an important role in the pathogenesis of diseases caused by h. pylori. since helicobacter infection is very important and effects many subjects for a long period, and since it has the potential of converting into cancer, we attempted to examine the role of il-19 cytokine in induction and continuation of this disease.
In this case-control study, blood samples of 100 patients and 100 healthy individuals was examined for gene polymorphisms of il-19 at rs2243191 position in patients with h. pylori infection. genotype of this polymorphism was determined by pcr- arms method. statistical data analysis of genomic was carried out by the x 2 (chi square).
In this investigation, data shows that there is no significant different in genotype and allele frequency at rs2243191 position between patients and control subject. (p = 0.65 or = 0.65 (ci; 0.35-1.28)).
It seems that there is no relationship between il-19 gene polymorphism at position( rs2243191) and susceptibility to h.pylori infection.