1. Medical Biotechnology Department, Biotechnology Research Center, Semnan University of Medical Sciences 2. Medical Biotechnology Department, Biotechnology Research Center, Semnan University of Medical Sciences
Synthetic biology is an emerging technology that combines the engineering principles with biology to design and construct new biological devices as well as re-design the natural biological systems for practical aims such as developing diagnostic and treatment tools for detecting and or killing cancer cells by genetically engineered bacteria, t cells and viruses. the natural regulation and detection systems were used by synthetic biology for the rational design of the biological sensors.
This is a review paper.
In recent years, synthetic biology has played a significant role in applying fundamental biological discoveries for the development of cancer-targeting synthetic receptors, switches, and genetic circuits to manage bacteria and t cell activity against tumors. therefore, synthetic biology approaches can be used to solve many of the important challenges associated with anti-cancer therapies.
In this review article, we survey recent advances in the development of biological diagnostic and therapy systems based on synthetic biology methods. also there is a particular focus on how to use standard biological parts for constructing the biological sensors and the role of these sensors in medical science including early stage detection of cancer biomarkers.