Physical activity is a non-pharmacological intervention for the treatment of obesity and metabolic syndrome in overweight girls

Mehdi Kushkestani,1,* Bakhtiyar tartibian ,2



Overweight and obesity in children and adolescents is one of the most important public health problems across the world. the lack of balance and increased lipoprotein-derived adipositokins can play important roles in development of diseases associated with obesity such as diabetes and metabolic syndrome. the aim of this study was to measure changes in leptin serum and adiponectin levels in overweight girls after 12 weeks of moderate endurance training.


In this semi-experimental study, 19 overweight girls aged between 8 to 12 years participated voluntarily. the levels of leptin and adiponectin serum in fasting state, pre-test, and post-test were collected after 12 weeks of aerobic training. leptin and adiponectin were measured and recorded by elisa method. pearson correlation coefficient, regression analysis and inverse t-test were used to analyze the data.


The statistical analysis showed a significant increase in adiponectin levels after 12 weeks of endurance training (p <0.05). there was a significant correlation between levels of adiponectin serum with leptin, fat percentage and body mass index, as well as between leptin and bmi (p <0.05).


The findings of this study indicate that moderate intensity aerobic exercise induces significant changes in adipokines, body composition and body mass index in overweight girls in pre-pubertal ages, which in fact suggests the positive effect of aerobic exercise in moderating and treating diseases-related obesity.


Leptin, adiponectin, fat, girls, physical activity