How could poly glycerol sebacate be utilized as a drug delivery system more efficient?

Sana Pirmardvand chegini,1,* Jaleh varshosaz,2

1. Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Iran
2. Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Iran

Abstract

Introduction

One of important part in success a new drug delivery system is choose an appropriate carrier. poly (glycerol sebacate) (pgs) is a new biodegradable elastic polymer that has tunable mechanical properties, to match the requirements of intended applications by controlling curing time, curing temperature and reactants concentration. also this polymer have good bio-compatibility, and proper surface degradation profile. both glycerol and sebacic acid are endogenous components, thus, the degradation products of pgs are often naturally metabolized in the body. biocompatibility analysis in vivo indicates that pgs has a favorable tissue response with little inflammation a widely utilized biomaterial .

Methods

Pgs in drug delivery system: applications of pgs are being expanded to drug delivery. numerous studies have demonstrated that drugs which loaded in pgs are sustain release system which provide continuous maintenance of target drug concentration within the therapeutic window and reduced toxicity. some study have reported pgs geometries system was kept during the degradation period of 30 days in pbs and was released for 7 days.

Results

shortcoming of pgs as a carrier and improvment: for water soluble drugs loading into this polymer there are some challenges and pgs’s hydrophobic character alone is not good choice for them. pgs has some advantages and disadvantages. hydrophobic systems although exhibit a sustain release profile for water soluble drugs but don’t have sufficient capability of encapsulation and this is because of variation in physicochemical properties with each other during drug loading process refused the drugs. in order to achieve desire physical-chemical properties of pgs, using of its combination with an appropriate hydrophilic polymer could be effective. due to combination of hydrophilic-hydrophobic system could highlight these benefits and overcomes the shortcoming of pgs as drug delivery system. using of pgs combination with other polymer in drug delivery coating of pgs surfaces with biocompatible and natural base molecules such as laminin, fibronectin, fibrin, collagen types i/iii, gelatin and elastin and creating water soluble pgs with an amphiphilic nature by chemical interactions are some of improving the properties of pgs. these molecules are natural components of the cellular environment and coating with such molecules along with improving the characteristics as drug deliver system, will provide an additional impetus for improving the material–cell interactions and should expand the application potential of pgs .

Conclusion

In order to achieve desire physical-chemical properties of pgs, using of its combination with an appropriate hydrophilic polymer could highlight its benefits and overcomes the shortcoming of pgs as drug delivery system. using of pgs combination with other polymer in drug delivery coating of pgs surfaces with biocompatible and natural base molecules such as laminin, fibronectin, fibrin, collagen types i/iii, gelatin and elastin and creating water soluble pgs with an amphiphilic nature by chemical interactions are some of improving the properties of pgs.

Keywords

Pgs, poly (glycerol sebacate) , drug delivery, polymer improvement, nano-carriers