Rit2, ras superfamily member and its role in neurologic and psychiatric disorders: a narrative review

Yousef Daneshmandpour,1 Zahra bahmanpour,2 Mahsa tahmasebivand,3 Raza mousavi,4 Bahare khademi,5 Babak emamalizadeh,6,*

1. Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Ira
2. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
6. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Introduction

Neurologic disorders are of major problems throughout the world and affect millions of people. multiple studies have tried to explain the genetic factors behind neurologic diseases. one of the recently introduced genes is rit2, a member of ras superfamily, which plays fundamental roles in neurologic cells. in current study, we have reviewed reported functions of rit2 in neurologic disorders.

Methods

We have searched pubmed, proquest, embase and google scholar databases thoroughly to find articles about rit2 function in neuron cells and its reported variations in various neurologic disorders. in addition, using string database, we have analyzed the protein network of the rit2 in neurologic disorders.

Results

Sixteen studies reported the rit2 gene variants in patients with neurologic disorders. in articles, rs12456492 has been associated with parkinson disease and essential tremor, rs16976358 with autism spectrum disorder, schizophrenia and bipolar disorder, rs4130047 with autism spectrum disorder and cnvs with schizophrenia. protein network of rit2 has six experimentally determined connections (pou4f1, ntrk1, ngf, braf, rit1, and tecr) which play important roles in neurologic disorders including noonan syndrome, non-syndromic mental retardation, parkinson’s disease and alzheimer’s disease, dementia and depression.

Conclusion

Our review have summarized the rit2 role in neurologic disorders. various variations of this gene in neurologic disorders have been reported. more investigations are still required to reach the exact functional role of each variant in rit2 protein and neurologic disorders.

Keywords

Neurological disorder · neurodegenerative disorder · rit2 · ras