1. Department of the pharmaceutical sciences, college of pharmacy, Tehran branch, Islamic Azad University, Tehran, Iran 2. Food and Drug Laboratory Research Center, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran
In this study, different imported and domestic patches of skin that were in a good appearance and have a production date and appropriate expiry date, each with three replications from different series of production randomly from the level of pharmacies (supply level) were collected and their zinc content was evaluated.
Since zinc level control in these samples is not the usual control of these drug systems, the amount of free and total zinc in each sample was measured by atomic absorption. to determine the concentration of zinc, the sample was injected into the atomic absorption device.
By knowing that 50 ppm of zinc produce the least amount of toxicity in the body, and the levels of 5000 ppm cause serious toxicity in the body, and the fact that the free zinc in most samples was less than 500 ppm.
Therefore it can be concluded that according to the ph conditions of the skin, the use of internal patches with this property produces minimal toxicity. also, some of the patches had a free and total zinc more than the permitted limits in comparison to the in-house samples that are more prone to toxicity. therefore, control of zinc level of skin patch samples is recommended.
Dermal patches, zinc oxide, drug delivery, pharmacopoeia, heavy element