1. Department of Plant Science and Biotechnology, Faculty Of Life Science And Biotechnology, Shahid Beheshti University, Te 2. Departmant of Biotechnology, Faculty of Agricultural s 3. Department of Plant Science and Biotechnology, Faculty Of Life Science And Biotechnology, Shahid Beheshti University, Te 4. Department of Plant Science and Biotechnology, Faculty Of Life Science And Biotechnology, Shahid Beheshti University, Te
Abstract
Introduction
Interferon beta-1b protein is used to improve ms disease and reduce the number of attacks in patients. the purpose of this study is to analyze the evolution of interferon beta protein in mammals and analyze it in silico to predict the structural potential of interferon beta1b protein by bioinformatics tools.
Methods
Physiological and physicochemical properties of interferon beta-1b protein were also studied by protscale and protparam servers. the 3d structure of interferon beta-1b protein was examined using the swiss model server and its interactions with other proteins by the string platform.
Results
The results of phylogenetic analysis indicated that the human beta interferon protein showed the highest affinity in terms of the aminoacid structure of myotis daubentoni. investigations in the silico structure of beta-1b proteins indicate the presence of guidance links and the presence of pathway secretions. molecular activity has cytokine activity. the results of protein network analysis showed that there is the highest interaction between interferon beta-1b protein and interferon-1 receptor protein and interferon factor-3 regulator.
Conclusion
Generally, the results showed that interferon beta-1b protein is a protein with an effective but unstable regulatory role in vitro. bioinformatics analyzes conducted on interferon beta-1b protein provides biological fields for futures research.
