Association of selenoprotein s expression and its variants with metabolic syndrome in subjects with cardiovascular disease

Mojgan Gharipour,1,* Masoumeh sadeghi,2 Mansour salehi,3



Selenoproteins s (sels or vimp) may regulate cytokine production, and thus play a key role in the control of the inflammatory response. the present study assesses the expression of two variants of vimp in serum of cardiovascular subjects to achieve a probable metabolic syndrome (mets) pathway.


The study sample consisted of 136 iranian patients with cardiovascular disease (65 mets-affected and 71 mets un-affected individuals) in the selengene study. expression of two variants of vimp including vimp i and ii were analyzed in all subjects using real-time pcr and elisa.


The level of vimp was lower in mets+ compared to the mets- subjects (p <0.05). we found no significant differences in quantitative expression of vimp i and vimp ii in both groups. whereas vimp i has reverse correlation with fasting blood sugar (fbs) (r = -0.45, p= 0.009), we did not find any significant correlation between these variants with waist circumference, systolic and diastolic blood pressure and hdl–cholesterol. however, sels in protein level has negative correlation with wc (r = -0.171, p= 0.049) and positive correlation with hdl (r = 0.176, p= 0.046).


In the present assessment, it is evident that expression of vimp varies highly among individuals with mets as well as those without mets. so regarding the functional role of this protein, it is possible to be deduced lower expression of it leads to higher secretion of unfolded protein to the cytosol and outside the cell which cannot play their exact role in different pathways.


Selenoprotein s, variants, metabolic syndrome, cardiovascular disease