The effect of vitamin d on diabetes mellitus: a systematic review

Nazanin Sabbagh nezhad yazd,1,* Amir reza rafiee,2 Zohreh kalani,3

1. Student Bachelor of Nursing, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2. Student Bachelor of Nursing, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3. Faculty of Nursing Department

Abstract


Introduction

: diabetes mellitus is a common metabolic and non-infectious disorder that affects around 346 million people worldwide who have diabetes every 10 seconds in 1 patient population. this study was conducted in parallel to investigate the effects of vitamin d on diabetes mellitus.

Methods

This article is a systematic review using keywords diabetes mellitus, vitamin d at pubmed, science direct, and google scholar. the pubmed database was searched between 2017-2012 and found that 10 related articles were selected, of which 8 were from the clinical trial and 2 were reviewed. at science direct in between 2017-2014, 12 related articles were selected, which included 9 original research papers and 3 review articles and in the google scholar database, 6 english and persian articles were selected. these articles were submitted in full text and abstract.

Results

Vitamin d as an anti-inflammatory and immune modifying agent can improve self-immune status of type 1 diabetes as well as chronic inflammation caused by resistance to insulin secretion in type 2 diabetes. vitamin d stimulates insulin secretion by beta-pancreatic cells. it is the process of calcium-dependent insulin secretion, and vitamin d has an indirect effect by regulating the concentration of extracellular calcium and flow through the membrane of beta cells and insulin-sensitized environmental tissues. vitamin d is also associated with an increase in serum c-peptide levels indicating an increase in insulin levels.

Conclusion

: vitamin a improves the function of pancreatic beta. diabetics are encouraged to use vitamin d supplements and foods to improve their condition.

Keywords

Diabetes mellitus, diabetes mellitus, vitamin d