An update review about stem cell therapy for diabetes mellitus
Bahareh Golkhandanian,
1,*
1. Department of Biology, Faculty of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract
Introduction
Mesenchymal stem cells (mscs) are the most widely used stem cells of the human body because of successful isolation, and expansion for many years. it is explicit that diabetes mellitus (dm) is a widespread chronic disease. therefore, msc transplantation may be a beneficial treatment for both types of this disease. it is necessary to say also, embryonic stem cells (escs) offer an attractive source, for stem cell therapy in dm. however, clinical application of escs has several concerns including teratogenicity, immunogenicity, and ethical considerations. in this review, we will discuss some of the updates clinical trials of msc, and esc transplantation for diabetes in order to identify the latest ways to treat diabetes.
Methods
Using several internet search engines like google chrome, pubmed, and scopus. the articles collected from first of 2017 to present.
Results
In order to treatment of both type of dm, mesenchymal stem cells that play a role in repairing tissues such as bone, cartilage, muscle, tendon, and also, they support hematopoietic cells, and embryonic stem cells can help us, because stem cells characterized in part by a high capacity of self-renewal, and they have a high potential for differentiation.
Conclusion
In summary, by studying the latest articles we can conclude that msc, and esc transplantation despite concerns, and costs can be a beneficial treatment for dm, because these days stem cell therapy is one of the newest ways to treat diseases.
Keywords
Stem cell therapy, diabetes mellitus, mesenchymal stem cells, embryonic stem cells
