1. Department of biology, Tehran north branch, Islamic Azad University 2. Department of Cellular and Molecular Biology, Nour Danesh Institute Of Higher Education
Abstract
Introduction
Chronic lymphoid leukemia (cll) is the most common form of leukemia found in adults. cll is a monoclonal disorder that was distinguished by a progressive agglomeration of functionally incompetent lymphocytes. it is appraised to have one of the highest familial risks for a hematologic malignancy; this along with other evidence strongly supports an inherited genetic component. recent genome-wide association studies (gwas) have identified some of the single nucleotide polymorphisms (snps) associated with increasing cll risk. present study aimed to evaluate the snps related to genetic susceptibility of cll (rs735665, rs11083846, rs872071, rs7176508) in iranian population.
Methods
It was studied four polymorphisms related to increase cll risk (rs735665, rs11083846, rs872071, rs7176508) in an independent sample of 50 cll cases and 100 controls. real time polymerase chain reaction polymorphism (real time pcr) and primer-specific pcr-based assays were used to assess them.
Results
Results were showed the significantly association between rs735665, rs872071 variants and cll risk (p<0.05). statistically significantly elevated ors for 4 snps and an elevated (rs735665 (odds ratio [or] =1.57; p = 0.02), rs872071 (or = 1.40; p = 1.72 × 10(-3)). there was no significance association for rs11083846 and rs7176508. no case was detected with those alleles.
Conclusion
The results have been showed some of the genetic variation may cause to increase chronic lymphoid leukemia risk. therefore, they might contribute to early diagnose people with high cll risk.
