The effects of methanolic soy extract on ovary tissue modification in model of polycystic ovary syndrome as an inflammation state

Sanaz Alivandi farkhad,1,* Homayoun khazali,2 Faezeh fatemi,3



Introduction and objective: chronic low-grade subclinical inflammation has been increasingly recognized as an interposer in the endocrine, metabolic and reproductive disturbances that characterize the polycystic ovary syndrome (pcos). flavonoids consist of a large group of phenolic compounds that are widely distributed in plants. they have been well-known for their antioxidant and anti-inflammatory health benefits. within this family, the focus of research has been on a subclass, isoflavones, which are mainly found in soy beans.


Methods: in this study the syndrome induced by muscular injection of 40 mg/kg estradiol valerate to 32 adult female wistar rats (weighing 170-180 g). control group receive no injection. after induction of pcos (60 days) the animals divided to control, pcos and pcos treated (soy extract) groups. treatment groups received 50 and 100 mg/kg methanolic soy extract orally by gavage for 21 days. at the end of experiment, the ovaries of all groups were dissected out for histological study.


Results and discussion: there was a signification polycystic improvement in ovaries treated with soy extract in comparison with pcos group and also granulosa layer increase, thickness of the theca layer decrease, reduction of cystic follicular number and corpus luteum increase were found.


Conclusion: it is possible that, this ability is because of soy antioxidant and anti-inflammatory effects that motivate reduction of cysts number and natural development of follicles.


Keywords: soy; polycystic ovary syndrome; inflammation; reproductive disturbance.