Matrix metalloprotease-9 (mmp-9) and premature myocardial infarction: a systematic review and meta-analysis

Mehrdad Sheikhvatan,1,* Mohammad ali boroumand,2 Mehrdad behmanesh,3

1. Iran University of Medical Sciences
2. Tehran University of Medical Sciences
3. Tarbiat Modarres University



Current findings on the role of matrix metalloproteases (mmps) in cardiac remodelling and the outcome after acute premature myocardial infarction (apmi) in both animal and human models are now under assessed. we aimed to systematically assess the role of mmp-9 potential polymorphisms in predicting apmi and its prognosis.


The method of this systematic review has been documented in a published protocol in the preferred reporting items for systematic review and meta-analysis (prisma). we performed a massive search in several search databases including pubmed/medline, embase, scopus, google scholar, cochrane, and web of science. pooled effects of mmp9 polymorphisms were estimated using relative risk with mantel-hansel risk ratio. all of the statistical analyses were done in stata, version 13.1.


In total, 27 citations were found in the initial literature search where 14 citations were excluded as they did not meet the inclusion criteria. the final number of studies available for analysis was 13 including 9 on -1562c>t polymorphism and 4 on r279q polymorphism. the pooled risk ratio for apmi linked to -1562c>t and r279q polymorphisms were 3.645 and 2.115 respectively indicating the critical role of these two polymorphisms to predict apmi in young population. none of the polymorphisms could predict long-term adverse cardiac event in such patients. a significant heterogeneity was observed in the overall analysis with i^2 heterogeneity percentage of 65.6% and 73.2%, respectively.


C1562t and r279q polymorphisms on mmp-9 are associated with the susceptibility to premature apmi, but cannot predict long-term cardiac events in such patients.


Matrix metalloproteases myocardial infarction meta analysis polymorphism