Effect of biochanin a on retinal angiogenesis and inflammation in stz induced diabetic rats
Maryam Eskandari mehrabadi,
1,* Zahra salemi,
2 Saeid babaei ,
3 Mitra panahi,
4
1. Department of Biochemistry, Arak University of Medical Sciences, Arak
2. Department of Biochemistry, Arak University of Medical Sciences, Arak
3. Department of histology, Arak University of Medical Sciences, Arak
4. Department of Biology, Alexander College, Vancouver, Canada
Abstract
Introduction
Without proper medication for the treatment of diabetic retinopathy (dr), retinal cells become malnourished and degenerate, which results to damage in vision cells and can lead to blindness. flavonoids such as biochanin a (bca) can directly target different facets of angiogenesis. we assessed the effect of administrating bca on angiogenic and inflammatory markers in the retina of diabetic rats.
Methods
: vegf, tnfα and il-1β were quantified in the retina of diabetic rats that received bca for 6 weeks, and for comparison, in the retina of control rats.
Results
Administration of bca to diabetic rats resulted in significant restoration of serum glucose and was associated with decreased vegf, tnf-α and il-1β.
Conclusion
: administration of bca can improve and postpone retinopathy, by lowering blood sugar, suppressing inflammation via decreasing tnf-α and il-1β, and reducing angiogenesis via decreasing vegf in the retinal tissues
Keywords
Diabetic retinopathy, hyperglycemia, biochanin a (bca), angiogenesis
