The role of viral proteins vp24 and vp35 in the pathogenesis of the ebola virus

Davoud Saedi,1,* Morahem ashengroph,2

1. The MSc in Molecular Cell Biology, Department of Biological Sciences
2. Assistant Professor of Microbiology, Department of Biological Sciences, Faculty of Sciences, University of Kurdistan

Abstract


Introduction

The ebola virus is a member of the filoviridae family, which is causing hemorrhagic and fatal fever to humans. ebola is a single-stranded polarized rna virus that encodes seven structural proteins. the viral proteins vp24, vp35 are known as major factors to pathogenesis of ebola virus.

Methods

This research is a review article by reviewing the cited articles of the pubmed database between 2005 and 2017.

Results

Vp35 and vp24 inhibit the interferon production and signaling pathways. the inhibitor domain of vp35 binds to dsrna in the host cell and prevents binding it to the (rig-i) and (mda-5) receptor .these proteins inhibit the expression of type i interferon by disrupt the phosphorylation of interferon-regulatory factors (irf3 and irf7). vp35 inhibits the dendritic cells maturation through disturbance in the rig-i signaling pathway that leads to stopping regulation of mhc i and ii, cd40 and cd80 molecules. vp24 stops the interferon production by inhibition of the jak / stat signaling pathway. these events prevent the antigen delivery to cd8 + and cd4 + cells, that cause to stop immune response.

Conclusion

Investigate the pathogenicity mechanism of ebola virus provides a new opportunity to understand the importance of this disease and reduce the mortality of it.

Keywords

Ebola virus،vp24، vp35 ،hemorrhagic fever