A technical overview on the neuronal dysfunction induced by heat stroke on the c57 mice models

Aida Aghazadeh,1,* Mohammad ali hosseinpourfeizi ,2 Leila mahdizadeh fanid ,3 Javad mahmudi ,4



Heat is an environmental hazard that via increasing core body temperature leads to innate stress with pathological and physiological consequences in different body organs. heat stress known as a condition that rise core body temperature above normal range. once, elevated core body temperature exceeds 40°c, it defined as heat stroke which can causes neuronal abnormalities. cerebral tissue is vulnerable to deleterious effects of heat stroke so that it causes delirium, convulsions and irritability, cognitive impairments and coma as well.


In the present study, there were four main groups of c57 mice. three groups were treated by a special protocol of heat stress (one group was determined as control).in the next stage after surgery, we have isolated mice brain tissue. rna was extracted from tissue in order to evaluation of some related genes expression. it was assessed by real time pcr.


Studies showed that heat stress can cause pathological effects on treated mice brain tissue in compare with control group. the results from real time pcr proved the alteration of genes expression.


: due to climate change and global warming, we aimed to examine pathological change of heat on brain to figure out molecular mechanisms of heat stress and genetical functions on nervous system.


Heat stress, heat stroke, neuronal abnormalities, cognitive impairments