1. islamic azad university east tehran branch 2. islamic azad university east tehran branch
Abstract
Introduction
Gastric cancer is one of the biggest health problems in the world. due to the lack of many carcinogenic biomarkers and the reduction of prognosis evaluation, the overall survival of gastric cancer is still disappointing despite the advancement of therapeutic techniques. pax5 is one of the members of the pax gene family participates in the differentiation of tissues and control of the development of organs. research has shown that pax5 is a very important tumor suppressor gene in gastric cancer, and p53 and met are direct targets for pax5 in gastric cancer cells. since gastrointestinal cancers, such as gastric cancer, are diagnosed in the last stages of the disease, and since molecular biomarkers play a very important role in early detection and screening of cancers, the aim of this study was to determine the level of pax5 expression in the blood samples of people with stomach cancer compared to normal people and their role as prognostic and diagnostic factors in gastric cancer.
Methods
In this study, pax5 gene expression was evaluated using real-time pcr technique in 35 blood samples of gastric cancer patients and 15 normal blood samples in iranian population.
Results
The results showed that the mean pax5 gene expression in blood samples of gastric cancer patients was reduced to normal blood samples.
Conclusion
The reduction of pax5 expression in blood samples of people with gastric cancer can be used as a biomarker for gastric cancer prognosis.
