Ischemia-modified albumin as an oxidative stress biomarker in acute coronary syndrome

Nastaran Mojibi,1,* Mehryar zargari,2 Mahboubeh gholipour,3 Zahra ghafouri,4

1. Mazandaran university of medical sciences, Sari, Student research committee, Iran
2. Department of Biochemistry and Genetic, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IR Iran
3. Guilan Interventional Cardiovascular Research Center, Department of Cardiology, Heshmat Hospital.
4. Department of Clinical Biochemistry, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.

Abstract

Introduction

Free radicals increasing or antioxidants decreasing may contribute to impair the equilibrium between oxidant and antioxidant levels, in this condition oxidative stress was occurred. oxidative stress is involved in the pathogenesis of many disease like atherosclerosis and acute coronary syndrome (acs). in this study, the levels of ischemia modified albumin (ima) and albumin-adjusted ima (adj-ima) were measured to investigate the association between these and albumin and total antioxidant capacity (tac) in acs patients.

Methods

The study sample consist of 60 patients with acs and 30 age and sex matched as controls. serum levels of albumin, ima and tac were analyzed using colorimetric methods. the levels of adj-ima were calculated by the formula suggested by lippi et al (serum albumin concentration/median albumin concentration of the population ×ima value).

Results

Ima and adj-ima levels were significantly higher in acs diagnosed group compare to controls (p<0.05), whereas albumin and tac levels were found significantly lower in acs patients (p<0.05). the negative correlation between ima-adj and tac levels were statistically significant.

Conclusion

Our findings support the idea that impaired oxidant-antioxidant balance in favour of oxidants may play an important role in increased levels of ima in acs diagnosed patients and ima could be a new oxidative stress biomarker in these patients.

Keywords

Ischemia modified albumin, oxidative stress, acute coronary syndrome