Effects of serotonin on adiponectin secretion and leptin gene expresions in rats

Fariba Mahmoudi,1,* Fatemeh mohammadzadeh,2 Loftali masoomi,3

1. University of Moghegh arddabili

Abstract


Introduction

Serotonin is a neurotransmitter which stimulates the secretion of sexual hormones . the nuclei of hypothalamus involved in the controlling the reproductive process receive projections of serotonin neurons from brain stem. . adiponectin and leptin are peptides which inhibits or stimulates the hypothalamus- pituitary-gonadal axis activity respectively. goals: in the present study the effects of serotonin were investigated on adiponectin secretion and leptin gene expressions.

Methods

Ten wistar male rats weighing 220-250 g in two groups(n=5 in each group) received saline or serotonin(10µg) via third cerebral ventricle. blood samples were collected via tail vein. mean serum adiponectin concentrations were determined by elisa method. leptin gene expression in the hypothalamus was determined by polymerase chain reaction(pcr).

Results

Injection of 10µg serotonin significantly decreased mean serum adiponectin levels compared to control group. but it did not significantly decreased the mean relative leptin gene expression compared to control rats.

Conclusion

Decrease of adiponectin secretion may partly be involved in the mediating the effects of serotonin in the regulation of hypothalamus- pituitary- gonad axis activity.

Keywords

Key words: serotonin, adiponectin, leptin.