1. Islamic Azad university medical branch of tehran 2. Islamic Azad university medical branch of tehran
Abstract
Introduction
T-cells have the potential to extirpate abnormal cells. the genetic modification and characterization of t-cells with chimeric antigen receptors (cars) allow functionally distinct t-cell subsets to recognize specific tumor cells. the aim of this study is to review recent findings of strategies of cars as a therapeutic potential and safety approach in cancer therapy.
Methods
The search was done in electronic databases using the following keywords: chimeric antigen receptors and cancer therapy. in this review, we consider the properties of car therapy for tumors.
Results
Chimeric antigen receptor (car) t cells can be infused to patients who show resistance to conventional therapies. the impressive efficacy of cars to challenge cancer in early phases have fueled optimism for applying similar strategies for solid tumors. these strategies consist of specifications for certain tumor antigens, surrounding the tumor and penetrating its stroma, and the ability to maintain its cytotoxic properties through a hostile immunosuppressive milieu, which are challenging in every aspect and resulted in lower clinical success than hematological malignancies. the development of car is the new trend under investigation to overcome these obstacles in solid tumor therapy
Conclusion
Recent advances in chimeric antigen receptor t cell therapy in cancer have been rather impressive and raises hopes for its broad clinical utility in cancer treatment. also, these findings suggest that the modification of t-cells with cars could be a powerful approach for developing safe and effective cancer therapeutics.
