Anti-cancer effect of redroot pigweed as weed plant species

Hamideh Bakhshayeshan-agdam,1,* Nastaran sedghi,2 Seyed yahya salehi-lisar ,3 Majid mahdavi ,4

1. Department of Plant Sciences, Faculty of Natural Sciences, University of Tabriz, Tabriz
2. Department of Animal Sciences, Faculty of Natural Sciences, University of Tabriz, Tabriz
3. Department of Plant Sciences, Faculty of Natural Sciences, University of Tabriz, Tabriz
4. Department of Animal Sciences, Faculty of Natural Sciences, University of Tabriz, Tabriz

Abstract

Introduction

Leukemia cancer is currently one of the major causes of cancer-related deaths among humans. extracts of plants including weeds may be a potential source for treatments of leukemia cancer. redroot pigweed (amaranthus retroflexus l.) is a weed plant with well-known allelopathic effects. this plant has diverse therapeutic effects such as anti-cancer properties due to specific biochemicals such squalene and phenolic compounds which involving in its allelopathic interaction as well. current research aimed to investigate the anti-cancer potential of redroot pigweed on human acute promyelocytic leukemia (apl) cancer cell lines (nb4 cells).

Methods

In order to, ethanolic extract of studied plant and mtt assay were used for cell treatment and viability investigation, respectively.

Results

Results from mtt assay revealed that redroot pigweed ethanolic extract inhibits the viability and proliferation of nb4 cells, in a time- and dose-dependent manner. so that, 70% decline in viability of treated cells with 20 mg/ml of extract was observed after 72h.

Conclusion

Overally, this study demonstrates the potential of redroot pigweed chemical's application as an anti-cancer drug for leukemia cancer treatment. besides, this investigation showed relation between plant allelopathic traits and its anti-cancer potential. accordingly, conducting similar research can lead to appearance novelty view in relation between allelopathy phenomenon as an important problem in agriculture and plants anti-cancer potential. in line with the goals pursued in this study, investigation of the action mechanisms of redroot pigweed that underlie its anti-cancer effects in human leukemia cancer cell is suggested.

Keywords

Acute promyelocytic leukemia (apl), allelopathy, redroot pigweed, ethanolic extract