Modification of genetic alterations effects on brain tumor risk: substantial role of dietary factors
Modification of genetic alterations effects on brain tumor risk: substantial role of dietary factors
Fatemeh Vaghefi,1Fatemeh Karami,2,*SayedAlireza Mousavi,3
1. Department of Biology, School of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Islamic Republic of Iran 2. Department of Medical Genetics, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Islamic Republic of Iran 3. Department of Biology, School of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Islamic Republic of Iran
Introduction: Brain tumors usually arise in familial cancer predisposition syndromes or tend to be clustered in families. Owing to the role of lifestyle modulation on decreasing the chance of disabling the remained wild alleles, preventive personalized diet have been recently studied in various types of cancer as well as brain tumor. Present study was aimed to review the dietary factors that may change the risk in high risk individuals.
Methods: We explored the internet in Google Scholar, Pubmed, Pubmed Central and Bing search engines using main key words including Breast cancer risk, gene polymorphism, gene expression, variant and dietary factors. All the manuscripts after 2000 were included in the present review.
Results: Among different dietary factors, it was found that polyunsaturated fatty acids (PUFA) can change the risk of brain tumors through affecting the expression of mTOR, immunocompromising and inflammatory cytokines, cell cycle and proapoptotic genes.
Conclusion: Owing to the contradictory results on different parts and types of diet on modulation of brain tumor pathogenesis, further studies are warranted to determine the exact quantity of different foods, vegentables and even supplements on either prevention or treatment of brain tumors.